Chelate synthesis of 3-ethoxycarbonyl-4-hydroxy-2-trifluoromethylpyridine from ethyl acetoacetate and trifluoroacetonitrile期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Chelate synthesis of 3-ethoxycarbonyl-4-hydroxy-2-trifluoromethylpyridine from ethyl acetoacetate and trifluoroacetonitrile

Authors:	V. A. Dorokhov L. S. Vasil'ev F. E. Surzhikov V. S. Bogdanov

Affiliation:	(1) N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp, 117913 Moscow, Russian Federation

Abstract:	Ethyl 2-acetyl-3-amino-4,4,4-trifluoro-2-butenoate was synthesized by treatment of ethyl acetoacetate with CF₃CN in the presence of Ni(acac)₂. Condensation of the diphenylboron chelate of the former with dimethylformamide dimethylacetal followed by refluxing in ethanol yielded 3-ethoxycarbonyl-4-hydroxy-2-trifluoromethylpyridine.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1329–1331, July, 1995.This study was financially supported by the Russian Foundation for Basic Research (Grant No. 94-03-08964).

Keywords:	ethyl acetoacetate trifluoroacetonitrile Ni(acac)₂ catalysis ethyl 2-acetyl-3-amino-04,4,4-trifluoro-2-butenoate boron chelates dimethylformamide dimethylacetal 3-ethoxycarbonyl-4-hydroxy-2-trifluoromethylpyridine
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