Copper‐Catalyzed Aerobic Oxidative NS Bond Functionalization for CS Bond Formation: Regio‐ and Stereoselective Synthesis of Sulfones and Thioethers |
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| Authors: | Xianwei Li Yanli Xu Dr Wanqing Wu Chang Jiang Dr Chaorong Qi Prof Dr Huanfeng Jiang |
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| Institution: | School of Chemistry and Chemical Engineering, South China University of Technology |
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| Abstract: | A regio‐ and stereoselective synthesis of sulfones and thioethers by means of CuI‐catalyzed aerobic oxidative N?S bond cleavage of sulfonyl hydrazides, followed by cross‐coupling reactions with alkenes and aromatic compounds to form the C ?S bond, is described herein. N2 and H2O are the byproducts of this transformation, thus offering an environmentally benign process with a wide range of potential applications in organic synthesis and medicinal chemistry. |
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| Keywords: | C H functionalization copper oxygen sulfones thioethers |
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