Pd‐Catalyzed Decarboxylative Cross‐Coupling of 2‐Carboxyazine N‐Oxides with Various (Hetero)aryl Halides |
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| Authors: | Jean‐Baptiste Rouchet Dr. Cédric Schneider Dr. Cédric Spitz Johan Lefèvre Prof. George Dupas Dr. Corinne Fruit Prof. Christophe Hoarau |
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| Affiliation: | 1. Normandie University, COBRA, UMR 6014 et FR 3038, University Rouen;2. INSA Rouen;3. CNRS, IRCOF, 1 rue Tesnière 76821 Mont‐Saint‐Aignan Cedex (France) |
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| Abstract: | ![]()
Decarboxylative cross‐coupling reactions of substituted 2‐carboxyazine N‐oxides, with a variety of (hetero)aryl halides, by bimetallic Pd0/CuI and Pd0/AgI catalysis are reported. Two possible pathways, a conventional bimetallic‐catalyzed decarboxylative arylation, as well as a protodecarboxylative/direct C?H arylation sequence have been considered. These methods provide the first general decarboxylative arylation methodology for the 2‐carboxyazine series. |
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| Keywords: | 2‐carboxyazine N‐oxides catalysis cross‐coupling palladium |
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