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Palladium‐Catalyzed Carbonylative α‐Arylation to β‐Ketonitriles |
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| Authors: | Johannes Schranck Mia Burhardt Christoph Bornschein Dr Helfried Neumann Prof?Dr Troels Skrydstrup Prof?Dr Matthias Beller |
| Institution: | 1. Leibniz‐Institut für Katalyse e.V. an der Universit?t Rostock, Albert‐Einstein‐Stra?e 29a, 18059 Rostock (Germany), Fax: (+49)?381‐1281‐5000;2. Center for Insoluble Protein Structures (inSPIN), Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C (Denmark), Fax: (+45)?8619‐6199 |
| Abstract: | A carbonylative α‐arylation process employing unactivated nitriles for the first time is described. The reaction tolerates a range of (hetero)aryl iodides and several nitrile coupling partners. No prefunctionalization of the nitriles is necessary and the resulting β‐ketonitriles are obtained in good to excellent yields. The methodology also allows for a convenient 13C‐labelling of the generated carbonyl moiety. |
| Keywords: | α ‐arylation β ‐ketonitriles carbonylation palladium |