A Fully Synthetic Glycopeptide Antitumor Vaccine Based on Multiple Antigen Presentation on a Hyperbranched Polymer |
| |
Authors: | Markus Glaffig Björn Palitzsch Sebastian Hartmann Dr Christoph Schüll Lutz Nuhn Dr Bastian Gerlitzki Prof?Dr Edgar Schmitt Prof?Dr Holger Frey Prof?Dr Horst Kunz |
| |
Institution: | 1. Johannes Gutenberg University Mainz, Institute of Organic Chemistry, Duesbergweg 10‐14, 55128 Mainz (Germany);2. Johannes Gutenberg University Mainz, University Medical Center‐Institute of Immunology, Langenbeckstrasse 1, Geb. 708, 55101 Mainz (Germany) |
| |
Abstract: | For antitumor vaccines both the selected tumor‐associated antigen, as well as the mode of its presentation, affect the immune response. According to the principle of multiple antigen presentation, a tumor‐associated MUC1 glycopeptide combined with the immunostimulating T‐cell epitope P2 from tetanus toxoid was coupled to a multi‐functionalized hyperbranched polyglycerol by “click chemistry”. This globular polymeric carrier has a flexible dendrimer‐like structure, which allows optimal antigen presentation to the immune system. The resulting fully synthetic vaccine induced strong immune responses in mice and IgG antibodies recognizing human breast‐cancer cells. |
| |
Keywords: | antitumor agents glycopeptides hyperbranched polymers polyglycerol tumor‐associated MUC1 |
|
|