Direct Enantioselective Three‐Component Synthesis of Optically Active Propargylamines in Water |
| |
| Authors: | Mutsuyo Ohara Yoshichika Hara Prof?Dr Tohru Ohnuki Prof?Dr Shuichi Nakamura |
| |
| Institution: | Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa‐ku, Nagoya 466‐8555 (Japan), Fax: (+81)?52‐735‐5245 |
| |
| Abstract: | An enantioselective three‐component reaction of aldehydes, amines, and alkynes in water by using a bis(imidazoline)–CuI catalysts having a hydrophobic substituent and sodium dodecyl sulfate as a surfactant was developed. The reaction was applied to a broad range of aldehydes and alkynes to give optically active propargylamines with excellent yields (up to 99 %) and enantiomeric excesses (up to 99 % ee). |
| |
| Keywords: | alkynylation enantioselectivity propargylamines three‐component reaction water |
|
|
