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Modulating Aβ33–42 Peptide Assembly by Graphene Oxide |
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| Authors: | Qiang Li Dr Lei Liu Shuai Zhang Meng Xu Xueqin Wang Prof Chen Wang Prof Flemming Besenbacher Prof Mingdong Dong |
| Institution: | 1. Interdisciplinary Nanoscience Center (iNANO), Aarhus University, 8000 Aarhus C (Denmark), Fax: (+45)?8942‐3690;2. Institute for Advanced Materials, JiangSu University, ZhenJiang 212013 (P.R. China);3. National Center for Nanoscience and Technology, Beijing 100190 (P.R. China) |
| Abstract: | Graphene oxide (GO) is utilized as the modulator to tune the formation and development of amyloid fibrils (Aβ33–42). Atomic force microscopy temporal evolution measurements reveal that the initial binding between the peptide monomer and the large available surface of the GO sheets can redirect the assembly pathway of amyloid beta. The results support the possibility to develop graphene‐based materials to inhibit amyloidosis. |
| Keywords: | amyloid peptides assembly graphene oxide modulated structures |