Copper‐Catalyzed Aerobic Oxidative Inert CC and CN Bond Cleavage: A New Strategy for the Synthesis of Tertiary Amides |
| |
| Authors: | Xiuling Chen Dr Tieqiao Chen Qiang Li Dr Yongbo Zhou Prof Li‐Biao Han Prof Shuang‐Feng Yin |
| |
| Institution: | State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410081 (P. R. China), Fax: (+86)?731‐88821171 |
| |
| Abstract: | A copper‐catalyzed aerobic oxidative amidation reaction of inert C?C bonds with tertiary amines has been developed for the synthesis of tertiary amides, which are significant units in many natural products, pharmaceuticals, and fine chemicals. This method combines C?C bond activation, C?N bond cleavage, and C?H bond oxygenation in a one‐pot protocol, using molecular oxygen as the sole oxidant without any additional ligands. |
| |
| Keywords: | aerobic oxidation amidation amides C C activation C N cleavage |
|
|
