Palladium‐Catalyzed Direct Thiolation of Aryl CH Bonds with Disulfides |
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| Authors: | Dr. Masayuki Iwasaki Miki Iyanaga Yuta Tsuchiya Yugo Nishimura Wenjuan Li Prof. Dr. Zhiping Li Prof. Dr. Yasushi Nishihara |
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| Affiliation: | 1. Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University, 3‐1‐1 Tsushimanaka, Kita‐ku, Okayama 700‐8530 (Japan), Fax: (+81)?86‐251‐7855;2. Department of Chemistry, Renmin University of China, Beijing 100872 (P. R. China);3. Japan Science and Technology Agency, ACT‐C, 4‐1‐8 Honcho, Kawaguchi, Saitama 332‐0012 (Japan) |
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| Abstract: | A catalytic variant of the direct thiolation of arenes, bearing directing groups, with disulfides or thiols has been developed under palladium and copper co‐catalysis. Both sulfenyl moieties of the disulfide could be incorporated into the thiolated products, therefore, the reactions reached completion with only half an equivalent of disulfide, with respect to the starting arene. Experimental evidence suggested that the reaction proceeds through a PdII/PdIV mechanism. |
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| Keywords: | 2‐arylpyridine aryl sulfides direct thiolation disulfides palladium |
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