Aryl‐Copper(III)‐Acetylides as Key Intermediates in CCsp Model Couplings under Mild Conditions |
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Authors: | Mireia Rovira Marc Font Ferran Acuña‐Parés Dr Teodor Parella Dr Josep M Luis Dr Julio Lloret‐Fillol Dr Xavi Ribas |
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Institution: | 1. Institut de Química Computacional i Catàlisi (IQCC) and Departament de Química, Universitat de Girona, Campus Montilivi, Facultat Ciències, E17071 Girona (Catalonia, Spain);2. Servei de RMN, Facultat de Ciències, Universitat Autònoma de Barcelona (UAB), Campus UAB, E‐08193 Bellaterra (Catalonia, Spain) |
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Abstract: | The mechanism of copper‐mediated Sonogashira couplings (so‐called Stephens–Castro and Miura couplings) is not well understood and lacks clear comprehension. In this work, the reactivity of a well‐defined aryl‐CuIII species ( 1 ) with p‐R‐phenylacetylenes (R=NO2, CF3, H) is reported and it is found that facile reductive elimination from a putative aryl‐CuIII‐acetylide species occurs at room temperature to afford the Caryl?Csp coupling species ( IR ), which in turn undergo an intramolecular reorganisation to afford final heterocyclic products containing 2H‐isoindole ( P , P , PHa ) or 1,2‐dihydroisoquinoline ( PHb ) substructures. Density Functional Theory (DFT) studies support the postulated reductive elimination pathway that leads to the formation of C?Csp bonds and provide the clue to understand the divergent intramolecular reorganisation when p‐H‐phenylacetylene is used. Mechanistic insights and the very mild experimental conditions to effect Caryl?Csp coupling in these model systems provide important insights for developing milder copper‐catalysed Caryl?Csp coupling reactions with standard substrates in the future. |
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Keywords: | Caryl Csp cross coupling copper(III) density functional calculations reaction mechanisms Pd‐free Sonogashira |
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