| 运动加强氟化钠对去卵巢大鼠骨元素代谢的影响效应 |
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| 引用本文： | 张兆强.运动加强氟化钠对去卵巢大鼠骨元素代谢的影响效应[J].广东微量元素科学,2008,15(8):20-23. |
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| 作者姓名： | 张兆强 |
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| 作者单位： | 广东医学院生理学教研室,广东,湛江,524023 |
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| 基金项目： | 广东省湛江市科技攻关项目 |
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| 摘 要： | 用测定骨元素含量的方法，观察了运动对氟化钠（NaF）抗去卵巢大鼠骨元素代谢的影响效应。将健康4月龄雌性SD大鼠30只，用抽签法随机分成5组：正常对照组，假去卵巢组，去卵巢组，去卵巢＋NaF组和去卵巢＋NaF＋运动组；去卵巢＋NaF组和去卵巢＋NaF＋运动组大鼠于去卵巢手术后第2天开始给予NaF溶液灌胃，1mg／（kg·BW），1次／d，持续11周；去卵巢＋NaF＋运动组大鼠于去卵巢术后第7天开始运动训练，每周5d，每天连续匀速跑45min，16m／min，跑道倾角0。，持续10周。结果表明，去卵巢大鼠骨Ca、S、Mg、Zn、Co、Mn等元素含量显著降低，骨P含量增加；NaF可使去卵巢大鼠降低的骨Ca、S、Mg、Co、Mn等元素含量回升，骨P含量回降；运动与NaF联合应用能使骨Ca、S、Mg、Zn、Co、Mn等元素含量显著回升，骨P含量显著回降。提示运动可加强NaF对抗由于去卵巢引起的大鼠骨元素代谢紊乱的作用。
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| 关 键 词： | SD大鼠 去卵巢 氟化钠 骨矿物元素 运动 |
Exercises Strengthens the Effect of Sodium Fluoride on Bone Minerial Element Metabolism in Ovariectomized Rats |
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| ZHANG Zhaoqiang.Exercises Strengthens the Effect of Sodium Fluoride on Bone Minerial Element Metabolism in Ovariectomized Rats[J].Trace Elements Science,2008,15(8):20-23. |
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| Authors: | ZHANG Zhaoqiang |
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| Institution: | ZHANG Zhaoqiang ( Department of Physiology, Guangdong Medical College, Guangdong Zhanjiang 524023, China) |
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| Abstract: | To investigate the influence of sodium fluoride (NaF) and exercises on bone mineral element metabolism in ovariectomized rats,30 female Sprague-Dawley (SD) rats were divided randomly into 5 groups.(1) normal control;(2) Sham ovariectomy;(3) ovariectomy (OVX);(4) NaF intake after OVX;(5) combined exercise and NaF after OVX.The results show that (1) Ca,S,Mg,Zn, Co,Mn reduce and P increases in the bone of the OVX rats;(2) NaF opposes the changes of Ca,S, Mg,Co,Mn and P in the bone of the OVX rats;(3) Exercise strengthens the effect of NaF.It concluded exercise strengthens the effect of NaF on the changes of Ca,S,Mg,Zn,Co and P in the bone of the OVX rats. |
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| Keywords: | SD rat ovariectomy sodium fluoride bone mineral element exercises |
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