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New paradigms for synthetic pathways inspired by bioorganometallic chemistry |
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| Authors: | G rard Jaouen, Siden Top, Anne Vessi res,Roger Alberto |
| Affiliation: | a Ecole Nationale Supérieure de Chimie de Paris, Laboratoire de Chimie Organométallique, UMR 7576, 11 rue Pierre et Marie Curie, F-75231 Paris Cedex 05, France b Anorganisch-Chemisches Institut, Universitat Zürich, Winterthurerstr. 190, 8057 Zürich, Switzerland |
| Abstract: | Two series of particular examples of reactions used in bioorganometallic chemistry are described. One based on a decomplexation-complexation reaction, indicates how, starting from a cymantrenyl derivative, a range of organometallic complexes bearing various metals can be prepared. The second one refers to the easy synthesis in water of the very versatile Alberto's reagent, which leads to new organometallic radiopharmaceuticals of Tc and Re. |
| Keywords: | Radiopharmaceuticals Metal exchange reaction Decomplexation-complexation Aqueous carbonyl complexes Hormones/antihormones Rhenium Technetium Iron Titanium complexes |
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