Application of macroautoradiography and instantimage in radiopharmaceutical research |
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| Authors: | Jeng-Jong Hwang Tzu-Chen Yen Bor-Tsung Hsieh Gann Ting |
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| Institution: | (1) Institute of Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, R.O.C.;(2) Department of Nuclear Medicine, Chang Gung Memorial Hospital, Taipei Medical Center and Chang Gung University, Taipei, Taiwan, R.O.C.;(3) Institute of Nuclear Energy Research, Lung-Tan, Taiwan, R.O.C. |
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| Abstract: | The evaluation of the pharmacokinetics of pure, beta radiopharmaceuticals is not possible with scintigraphy. Both whole-body
autoradiography (WBAR) and Packard Instantimager, a device for rapid imaging, were used to study the whole body distribution
of γ- and β-emitting radionuclides (99mTc-MDP,99mTc-sulfur colloid, or188Re-HEDP), and results obtained from both methods were compared. The biodistribution of99mTc-MDP and188Re-HEDP were seen mainly in bones including skull, spine, and vertebrae of spine and cardiac and skeletal muscles. The99mTc-sulfur colloid localized in liver, bone marrow, and spleen. The resolution of WBAR is superior than that of Packard Instantimager.
However, the advantage of Packard Instantimager is that rapid imaging within few minutes is possible with it, while WBAR imaging
requires several hours to days. |
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