Optimization of the sensitivity and stability of the PRESAGE? dosimeter using trihalomethane radical initiators |
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| Authors: | Mamdooh Alqathami Anton Blencowe Greg Qiao Duncan Butler Moshi Geso |
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| Institution: | 1. The Royal Melbourne Institute of Technology, Melbourne 3083, Australia;2. Department of Chemical & Biomolecular Engineering, the University of Melbourne, Melbourne 3052, Australia;3. The Australian Radiation Protection and Nuclear Safety Agency, Melbourne 3085, Australia;1. Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, CONICET, Córdoba, Argentina;3. Departamento de Física, Universidad Nacional, Heredia, Costa Rica;4. Facultad de Matemática, Astronomía y Física, Universidad Nacional de Córdoba, Córdoba, Argentina; Instituto de Física Enrique Gaviola, CONICET, Córdoba, Argentina;5. Instituto de Física Enrique Gaviola, CONICET, Córdoba, Argentina;6. Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina;7. Instituto Multidisciplinario de Biología Vegetal, CONICET, Argentina;1. Department of Energy, Nuclear Engineering Division, Politecnico di Milano, Milano, Italy;2. Department of Chemistry, University of Pavia, via Taramelli 12, 27100 Pavia, Italy;3. Calvin College, Department of Chemistry and Biochemistry, Grand Rapids, MI, United States;4. Istituto Nazionale di Ricerca Metrologica (INRIM), Unit of Radiochemistry and Spectroscopy, c/o Department of Chemistry, University of Pavia, via Taramelli 12, 27100 Pavia, Italy;1. Department of Chemistry and Life Science, Yokohama National University, 79-5 Tokiwadai, Hodogaya-ku, Yokohama, Japan;2. Toshiba Energy Systems & Solutions Corporation, Kawasaki, Japan;3. Kanagawa Cancer Center, Yokohama, Japan;1. Rinecker Proton Therapy Center, Munich, Germany;2. Department of Medical Physics, Faculty of Physics, Ludwig-Maximilians-Universität München (LMU Munich), Munich, Germany;3. Medical Physics Laboratory, Medical School, National and Kapodistrian University of Athens, Greece;4. Department of Medical Physics, University of Crete, Heraklion, Greece;5. Department of Radiology, University Hospital, LMU Munich, Munich, Germany;6. Radiology & Radiotherapy Sector, Department of Biomedical Sciences, University of West Attica, Athens, Greece |
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| Abstract: | The aim of this study is to investigate the effect of trihalomethane radical initiators on the radiological properties, radiation dose sensitivity and post response photo-stability of the PRESAGE dosimeter. Different PRESAGE dosimeters containing 50 and 100 mM of iodoform (CHI3), bromoform (CHBr3) or chloroform (CHCl3) radical initiators where fabricated and irradiated with 6 MV photons for a range of radiation doses from 0 to 30 Gy. A comparison between sensitivity and radiological properties of the PRESAGE dosimeters with the different radical initiators was carried out. Optical density changes of the dosimeters before and after irradiation were measured using a spectrophotometer. The incorporation of different radical initiators in the composition of the PRESAGE dosimeter resulted in variation of the radiation dose sensitivity and radiological properties of the dosimeters depending on the type and concentration of the radical initiator used, with iodoform showing the highest dose-response slope followed by bromoform and chloroform. However, at 100 mM iodoform, the effective atomic number was significantly higher than water (Zeff=16). This enhancement in dose-response was found to be directly related to the carbon–halogen bond dissociation energy and to the radiological properties of each individual radical initiator used in this study. Furthermore, the post-response stability of the PRESAGE dosimeters over two weeks remained stable regardless of the trihalomethane radical initiator employed, with negligible change in the post-response stability and linearity of the PRESAGE dosimeters. |
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