Degradation behavior of poly (l-lactide-co-glycolide) films through gamma-ray irradiation |
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| Authors: | Sun-Young Jo Jong-Seok Park Hui-Jeong Gwon Young-Min Shin Myung-Seob Khil Young-Chang Nho Youn-Mook Lim |
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| Affiliation: | 1. Medicine, University of Texas Health Science Center and South Texas Veterans Health Care System, San Antonio, TX 78229, United States;2. Heart & Vascular Institute, Tulane University School of Medicine, New Orleans, LA 70112, United States;3. Laboratory of Immunoregulation, NIAID/NIH, Bethesda, MD 20892, United States;4. Research Service, Southeast Louisiana Veterans Health Care System, New Orleans, LA 70161, United States;1. University of Colorado—Denver, Aurora, CO, USA;2. Stryker Joint Preservation, Mahwah, NJ, USA |
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| Abstract: | Gamma-ray irradiation is a very useful tool to improve the physicochemical properties of various biodegradable polymers without the use of a heating and crosslinking agent. The purpose of this study was to investigate the degradation behavior of poly (l-lactide-co-glycolide) (PLGA) depending on the applied gamma-ray irradiation doses. PLGA films prepared through a solvent casting method were irradiated with gamma radiation at various irradiation doses. The irradiation was performed using 60Co gamma-ray doses of 25–500 kGy at a dose rate of 10 kGy/h.The degradation of irradiated films was observed through the main chain scission. Exposure to gamma radiation dropped the average molecular weight (Mn and Mw), and weakened the mechanical strength. Thermograms of irradiated film show various changes of thermal properties in accordance with gamma-ray irradiation doses. Gamma-ray irradiation changes the morphology of the surface, and improves the wettability. In conclusion, gamma-ray irradiation will be a useful tool to control the rate of hydrolytic degradation of these PLGA films. |
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