Studies on the biosynthesis of phomoidride B (CP-263,114): evidence for a decarboxylative homodimerization pathway |
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| Authors: | Sulikowski Gary A Agnelli Fabio Spencer Paul Koomen John M Russell David H |
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| Institution: | Department of Chemistry, Texas A&M University, College Station, Texas 77842, USA. sulikowski@mail.chem.tamu.edu |
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| Abstract: | reaction: see text]. Feeding experiments using a deuterium labeled C16 maleic anhydride and whole cell culture of ATCC 74256 led to the isolation of phomoidride B with deuterium incorporation at C(7) and C(19) as determined by 2H NMR and electrospray mass spectrometry. This result is in accord with a decarboxylative homodimerization of the C16 maleic anhydride as a key biosynthetic step leading to phomoidride B. |
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