| Synthesis and Crystal Structures of Novel Keggin and Dawson Polyoxometalates Containing Amantadine |
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| 引用本文： | Shu Xia LIU*,Chun Mei WANG,Hong Ju ZHAI,De Hui LI,En Bo WANG Institute of Polyoxometalate Chemistry,Department of Chemistry,Northeast Normal University,Changchun 130024. Synthesis and Crystal Structures of Novel Keggin and Dawson Polyoxometalates Containing Amantadine[J]. 中国化学快报, 2004, 15(2): 216-219 |
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| 作者姓名： | Shu Xia LIU* Chun Mei WANG Hong Ju ZHAI De Hui LI En Bo WANG Institute of Polyoxometalate Chemistry Department of Chemistry Northeast Normal University Changchun 130024 |
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| 作者单位： | Shu Xia LIU*，Chun Mei WANG，Hong Ju ZHAI，De Hui LI，En Bo WANG Institute of Polyoxometalate Chemistry，Department of Chemistry，Northeast Normal University，Changchun 130024 |
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| 摘 要： | Heteropolyoxometalates are a large family of potent medicines due to their excellent antiviral and antitumor activity 1-4, while their application in clinic meets great difficulties for their toxicity 5. How to synthesize heteropolyoxometalate medicines possessing high activity and low toxicity has become the focus in heteropolyoxometalate medicine research. Previously reported polyoxometalates showing medical activities are all salts simple Na+, K+ or NH4+ etc. inorganic cations, in which o…
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| 关 键 词： | 金刚胺 合成 聚金属氧化物 晶体结构 |
Synthesis and Crystal Structures of Novel Keggin and Dawson Polyoxometalates Containing Amantadine |
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| Shu Xia LIU,Chun Mei WANG,Hong Ju ZHAI,De Hui LI,En Bo WANG Institute of Polyoxometalate Chemistry. Synthesis and Crystal Structures of Novel Keggin and Dawson Polyoxometalates Containing Amantadine[J]. Chinese Chemical Letters, 2004, 15(2): 216-219 |
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| Authors: | Shu Xia LIU Chun Mei WANG Hong Ju ZHAI De Hui LI En Bo WANG Institute of Polyoxometalate Chemistry |
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| Affiliation: | Shu Xia LIU*,Chun Mei WANG,Hong Ju ZHAI,De Hui LI,En Bo WANG Institute of Polyoxometalate Chemistry,Department of Chemistry,Northeast Normal University,Changchun 130024 |
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| Abstract: | Two novel polyoxometalates containing pharmaceutical component amantadine, formulated with (C10H18N) 5PMo12O40Cl2 5H2O (I) and (C10H18N) 6As2Mo18O62 6CH3CN 6H2O (II) were first synthesized and characterized by IR, UV-Vis spectra and X-ray diffraction. Structural analyses of I and II suggested that polyanions in these compounds were reserved their Keggin or Dawson structures and were linked to amantadine through electrostatic interaction and hydrogen bonding. |
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| Keywords: | Amantadine polyoxometalate synthesis crystal structure. |
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