| 7种喹诺酮类药物固体表面室温磷光或延迟荧光分析法研究 |
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| 引用本文： | 刘长松,董川,冯小花,晋卫军.7种喹诺酮类药物固体表面室温磷光或延迟荧光分析法研究[J].武汉大学学报(理学版),2000,46(6):649-654. |
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| 作者姓名： | 刘长松 董川 冯小花 晋卫军 |
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| 作者单位： | 山西大学,化学系,山西,太原,030006 |
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| 基金项目： | 国家自然科学基金资助项目(29875016)；山西省青年科学基金资助项目(981006)
国家自然科学基金资助项目(29875016)
山西省青年科学基金资助项目(981006) |
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| 摘 要： | 建立了滤纸为基质的7种喹诺酮类药物的固体表面室温磷光(SS-RTP)或延迟荧光(SS-DF)分析测定的新方法．对影响喹诺酮类药物发光强度的各种因素，包括介质pH条件、重原子种类、浓度等进行了详细的研究．实验表明，除氧氟沙星在pH=6．5条件下有较强室温磷光发射外，其余6种药物均在酸性条件下有较强RTP或DF发射，其适宜pH为1．6或1．8．方法的稳定性好，线性范围宽，检出限低．7种喹诺酮类药物在尿样中的回收率最大为104．3％，最小为97．7％，能够满足痕量分析的要求．
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| 关 键 词： | 喹诺酮类药物 固体表面室温磷光 固体表面延迟荧光 药物分析 |
| 文章编号： | 0253-9888(2000)06-0649-06 |
| 修稿时间： | 2000年4月20日 |
Study on the Solid Surface Room Temperature Phosphorimetry or Delayed Fluorescence of Seven Quinolones |
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| LIU Chang-song,DONG Chuan,FENG Xiao-hua,JIN Wei-jun.Study on the Solid Surface Room Temperature Phosphorimetry or Delayed Fluorescence of Seven Quinolones[J].JOurnal of Wuhan University:Natural Science Edition,2000,46(6):649-654. |
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| Authors: | LIU Chang-song DONG Chuan FENG Xiao-hua JIN Wei-jun |
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| Abstract: | The solid surface room temperature phosphorimetry (SS\|RTP) or the solid surface delayed fluorescence (SS\|DF) of seven kinds of quinolones, ciprofloxacin, fleroxacin, lomefloxacin, ofloxacin and pefloxacin, norfloxacin,pipemidic were first established with filter paper as a solid substrate.Various effect factors on SS\|RTP or SS\|DF intensity such as substrate,pH condition,selection of heavy ions and inference of their concentration,drying condition and the stability were studied in detail.The linear range, the detection limit and RSD for every kind of above quinolones were described and the discovery the pharmaceutical analysis results are satisfactory. |
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| Keywords: | quinolones solid surface room temperature phosphorimetry solid surface delayed fluorimetry pharmaceuticat analysis |
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