Facile synthesis of 4-substituted 1,2,4,5-tetrahydro-1,4-benzodiazepin-3-ones by reductive cyclization of 2-chloro-N-(2-nitrobenzyl)acetamides |
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| Authors: | Leandro D. Sasiambarrena Ivan A. Barri Guido G. Fraga Rodolfo D. Bravo Agustín Ponzinibbio |
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| Affiliation: | Centro de Estudio de Compuestos Orgánicos CEDECOR UNLP-CIC, Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, La Plata 1900, Argentina |
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| Abstract: | ![]()
A facile and efficient method was developed for the synthesis of 1,2,4,5-tetrahydro-1,4-benzodiazepine-3-ones from 2-chloro-N-(2-nitrobenzyl)acetamides through a reductive cyclization using iron-ammonium chloride in ethanol–water in good yields. This method provides a simple approach to these benzodiazepine-3-ones which are of high value in the field of medicinal chemistry research. |
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| Keywords: | 1,4-Benzodiazepines 2-Chloro-N-(2-nitrobenzyl)acetamides Iron-ammonium chloride reduction 2-Nitrobenzylamines |
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