1,6-Conjugate sulfonylation of para-quinone methides: An expedient approach to unsymmetrical gem-diarylmethyl sulfones |
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| Authors: | Xiao-Yu Guan Liang-Dong Zhang Peng-Sheng You Sheng-Shu Liu Zhang-Qin Liu |
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| Affiliation: | Key Laboratory of Applied Chemistry of Chongqing Municipality, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China |
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| Abstract: | ![]()
A novel sulfonylation of para-quinone methides with sodium arylsulfinates has been developed via acetic acid promoted sulfa-Michael addition. This reaction provides an inexpensive and efficient method to synthesize various unsymmetrical diarylmethyl sulfones, displaying the advantages of high atom economy, good functional group tolerance, scalability, and environmentally friendly operation. Derivations of target products are also demonstrated. |
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| Keywords: | Sulfonylation 1,6-Conjugated addition Diarylmethyl sulfones Sodium arylsulfinates |
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