Ethanol-induced changes in glycolipids of Saccharomyces cerevisiae |
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Authors: | Renuka Malhotra Balwant Singh |
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Institution: | (1) Department of Molecular Biology and Biochemistry, Guru Nanak Dev University, 143005 Amritsar, India |
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Abstract: | Total glycolipid content of Saccharomyces cerevisiae cells increased in ethanol-treated yeast cells. Sialic acid and hexosamine contents of glycolipids from ethanol-treated cells
decreased, whereas those of hexoses increased. Increased sialidase activity in the presence of ethanol may be responsible
for the decrease in sialic acid content of glycolipids. The saccharide moieties of glycolipids of S. cerevisiae consisted of fucose, mannose, galactose, and glucose. Ethanol treatment of yeast cells caused an increase in glucose and
a decrease in galactose content of glycolipids. The changes in glucose content can be related to changes in β-glucosidase
activity under alcohol stress. The content of cerebrosides, sulfatides, and monoglucosyldiglycerides was enhanced following
ethanol treatment. An increase in cerebroside as well as in sulfatide content during alcohol stress might play an important
role in stabilizing the membrane both physically and structurally. Such variations in glycolipid content and composition of
S. cerevisiae cells may represent an adaptive response to ethanol stress. |
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Keywords: | Saccharomyces cerevisiae glycolipids sugars ethanol |
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