Synthetic studies toward maytansinoids (2) a new strategy based on asymmetric induction by heteroconjugate addition of methyllithium onto pyranosyl hetero-olefins |
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Authors: | Minoru Isobe Masato Kitamura Toshio Goto |
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Institution: | Laboratory of Organic Chemistry, Faculty of Agriculture, Nagoya University, Chikusa, Nagoya 464, Japan |
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Abstract: | The functionalized pyranosyl hetero-olefins , and received a remarkable diastereoselective addition of methyllithium to form adducts, one of which was introduced into a possible synthetic intermediate as for maytansine () along Scheme I. |
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