Nucleic acid related compounds. 31. Smooth and efficient palladium-copper catalyzed coupling of terminal alkynes with 5-iodouracil nucleosides |
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Authors: | Morris J Robins Philip J Barr |
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Institution: | Department of Chemistry, The University of Alberta Edmonton, Alberta, Canada T6G 2G2 |
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Abstract: | Coupling of terminal alkynes with protected 5-iodouracil nucleosides in the presence of dichlorobis(triphenylphosphine)palladium and copper(I) iodide in triethylamine gives the corresponding 5-(alkyn-1-yl)uracil nucleosides in 72–92% yields. |
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