Synthesis of enantiopure imidazolines through a Ritter reaction of 2-(1-aminoalkyl)aziridines with nitriles |
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| Authors: | Concellón José M Riego Estela Suárez José Ramón García-Granda Santiago Díaz M Rosario |
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| Affiliation: | Departamento de Química Orgánica e Inorgánica y Departamento de Química Física y Analítica, Facultad de Química Universidad de Oviedo, Julián Clavería 8, 33071 Oviedo, Spain. jmcg@fq.uniovi.es |
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| Abstract: | ![]()
The Ritter reaction of enantiopure 2-(1-aminoalkyl)aziridines 1 with different nitriles afford enantiopure tetrasubstituted imidazolines 2. The opening of the aziridine ring takes place with total regio- and stereoselectivity. A mechanism to explain the described addition reaction is proposed. [reaction: see text] |
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