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| 苏型-N-苯甲酰基-3-苯基异丝氨酸甲酯的合成 | |
| 引用本文： | 周忠强,梅兴国,常俊丽. 苏型-N-苯甲酰基-3-苯基异丝氨酸甲酯的合成[J]. 应用化学, 2001, 18(4): 318-0 |
| 作者姓名： | 周忠强 梅兴国 常俊丽 |
| 作者单位： | 华中科技大学 |
| 基金项目： | 国家“九五”科技攻关项目(96-C-02-03-01) |
| 摘 要： | 紫杉醇;苏型-N-苯甲酰基-3-苯基异丝氨酸甲酯的合成 |
| 关 键 词： | 紫杉醇 苏型-N-苯甲酰基-3-苯基异丝氨酸甲酯的合成 |
| 文章编号： | 1000-0518(2001)04-0318-03 |
| 收稿时间： | 2009-06-29 |
| 修稿时间： | 2000-07-13 |
Synthesis ofThreo-N-Benzoyl-3- Phenylisoserine Methyl Ester |
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| ZHOU Zhong-qiang,MEI Xing-guo,CHANG Jun-li. Synthesis ofThreo-N-Benzoyl-3- Phenylisoserine Methyl Ester[J]. Chinese Journal of Applied Chemistry, 2001, 18(4): 318-0 | |
| Authors: | ZHOU Zhong-qiang MEI Xing-guo CHANG Jun-li |
| Affiliation: | ZHOU Zhong Qiang *,MEI Xing Guo,CHANG Jun Li |
| Abstract: | Threo N benzoyl 3 phenylisoserine methyl ester was synthesized. Compound 3 was first prepared from benzaldehyde and ethyl chloroacetate by Darzens condensation, then through ammonolysis, hydrolysis, acylation and methylation, erythro N benzoyl 3 phenylisoserine methyl ester was obtained. The C 2 configuration inversion of the latter compound affords the title compound in yield of 42%. The compound was characterized by IR, 1H NMR and elemental analysis. |
| Keywords: | taxol threo N benzoyl phenylisoserine methyl ester synthesis |
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