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A practical synthesis of [C4] N-benzylpiperazine from [C2] glycine
Authors:Fredrik LakeChristian Linde
Institution:Department of Medicinal Chemistry, AstraZeneca R&D Södertälje, SE-151 85 Södertälje, Sweden
Abstract:A high yielding gram-scale synthesis of 13C4] N-benzylpiperazine for use as a convenient and versatile building block in isotope labeling studies of clinical drug candidates is reported.
Keywords:13C  Isotope labeling  N-Benzylpiperazine  Glycine
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