Nagelamide J, a novel dimeric bromopyrrole alkaloid from a sponge Agelas species |
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Authors: | Araki Atsushi Tsuda Masashi Kubota Takaaki Mikami Yuzuru Fromont Jane Kobayashi Jun'ichi |
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Institution: | Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan. |
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Abstract: | A novel dimeric bromopyrrole alkaloid, nagelamide J (1), with antimicrobial activity has been isolated from an Okinawan marine sponge Agelas species, and the structure and stereochemistry were elucidated from spectroscopic data. Nagelamide J (1) is the first bromopyrrole alkaloid possessing a cyclopentane ring fused to an amino imidazole ring. |
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