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| 双核铜(Ⅱ)配合物在H2O2存在下对DNA的氧化切割活性 | |
| 引用本文： | 张寿春,邵颖. 双核铜(Ⅱ)配合物在H2O2存在下对DNA的氧化切割活性[J]. 无机化学学报, 2006, 22(9): 1733-1739 |
| 作者姓名： | 张寿春 邵颖 |
| 作者单位： | 1. 湖南大学化学化工学院,长沙,410082;南京大学配位化学国家重点实验室,南京,210093 2. 绍兴文理学院化学化工学院,绍兴,312000;南京大学配位化学国家重点实验室,南京,210093 |
| 摘 要： | A novel dinuclear copper(Ⅱ) complex, [Cu2(phen)(dipic)2(H2O)2]·2H2O (phen=1,10-phenanthroline, dipicH2=2,6-pyridinedicarboxylic acid), has been prepared and structurally characterized. The complex crystallizes in the triclinic system, space group P1 with cell parameters a=0.846 0(17) nm, b=1.289 5(3) nm, c=1.452 7(3) nm, α=77.42(3)°, β=79.11(3)°, γ=87.08(3)°, and V=1.518 8(6) nm3. The dinuclear complex shows potential DNA cleavage activity at micromolar concentration in the presence of H2O2 and exhibits higher nuclease efficiency than mononuclear complex [Cu(dipic)(H2dipic)]·H2O. Without external reductants, the added H2O2 may contribute to the generation of hydroxyl radicals that result in DNA strand scission.CCDC:291786. |
| 关 键 词： | 双核铜(II)配合物； DNA； 氧化切割； 晶体结构 |
| 文章编号： | 1001-4861(2006)09-1733-07 |
| 收稿时间： | 2006-05-23 |
| 修稿时间： | 2006-07-24 |
Oxidative Cleavage of DNA by a Novel Dinuclear Copper(Ⅱ) Complex in the Presence of H2O2 |
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| ZHANG Shou-Chun and SHAO Ying. Oxidative Cleavage of DNA by a Novel Dinuclear Copper(Ⅱ) Complex in the Presence of H2O2[J]. Chinese Journal of Inorganic Chemistry, 2006, 22(9): 1733-1739 | |
| Authors: | ZHANG Shou-Chun and SHAO Ying |
| Affiliation: | School of Chemistry and Chemical Engineering, Hunan University, Changsha 410082;State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093 and College of Chemistry & Chemical Engineering, Shaoxin University, Shaoxin, Zhejiang 312000;State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093 |
| Abstract: | A novel dinuclear copper (Ⅱ) complex, [Cu2 (phen) (dipic)2(H2O)2]·2H2O (phen =1,10-phenanthroline,dipicH2=2,6-pyridinedicarboxylic acid), has been prepared and structurally characterized. The complex crystallizes in the triclinic system, space group P1 with cell parameters a=0.846 0(17) nm, b=1.289 5(3) nm, c=1.452 7(3) nm, α =77.42 (3)°,β=79.11 (3)°, γ=87.08 (3)°, and V = 1.518 8 (6) nm3. The dinuclear complex shows potential DNA cleavage activity at micromolar concentration in the presence of H2O2 and exhibits higher nuclease efficiency than mononuclear complex [Cu(dipic)(H2dipic)]· H2O. Without external reductants, the added H2O2 may contribute to the generation of hydroxyl radicals that result in DNA strand scission. CCDC:291786. |
| Keywords: | dinuclear copper(II) complex DNA oxidative cleavage crystal structure |
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