Characterization of surface-confined ionic liquid stationary phases: impact of cation and anion identity on retention |
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Authors: | David S Van Meter Nyoté J Oliver A Björn Carle Sabine Dehm Thomas H Ridgway Apryll M Stalcup |
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Institution: | (1) Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221, USA;(2) Hochschule Reutlingen, 72762 Reutlingen, Germany |
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Abstract: | A series of surface-confined ionic liquid (SCIL) stationary phases for high-performance liquid chromatography were synthesized
in-house. The synthesized phases were characterized by the linear solvation energy relationship (LSER) method to determine
the effect of residual linking ligands and the role of the cation and the anion on retention. Statistical analysis was utilized
to determine whether the system coefficients returned from multiple linear regression analysis of chromatographic retention
data for a set of 28 neutral aromatic probe solutes were significantly different. Examination of the energetics of retention
via κ−κ plots agrees with the results obtained from the LSER analysis. Residual linking ligands were determined to contribute reversed-phase-type
retention character to the chromatographic system. Furthermore, retention on the SCIL phases was observed to be more profoundly
affected by the identity of the anion than by that of the cation. |
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Keywords: | Linear solvation energy relationship Retention mechanisms Surface-confined ionic liquids Ionic liquids Reversed-phase high-performance liquid chromatography κ − κ plots |
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