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Intramolecular Lewis-acid promoted (2+2) cycloadditions: An efficient total synthesis of (±)-coronafacic acid via an internal Diels-Alder reaction.
Authors:Michael E Jung  Kim M Halweg
Institution:Department of Chemistry, University of California Los Angeles, California 90024 U.S.A.
Abstract:Internal (2+2) cycloaddition of the ester 7 gave the cyclobutene 8 in fair yield; cyclization of the readily derived trienone 4 and hydrolysis produced coronafacic acid in 7% overall yield.
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