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Chloctanspirones A and B, novel chlorinated polyketides with an unprecedented skeleton, from marine sediment derived fungus Penicillium terrestre |
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| Authors: | Dehai Li Li ChenTianjiao Zhu Tibor Kurtán Attila MándiZhimin Zhao Jing Li Qianqun Gu |
| Institution: | a Key Laboratory of Marine Drugs, Chinese Ministry of Education, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, PR China b School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, PR China c Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, 2 Xueyuan Road, Fuzhou, Fujian 350002, PR China d Department of Organic Chemistry, University of Debrecen, POB 20, 4010 Debrecen, Hungary |
| Abstract: | Two novel chlorinated sorbicillinoids named chloctanspirones A (1) and B (2), possessing an unprecedented bicyclo2.2.2]octane-2-spiro cyclohexane skeleton, together with their quasi-precursors terrestrols K (3) and L (4), two additional new chlorinated compounds, were isolated from a marine sediment derived fungus Penicillium terrestre. Their structures including absolute stereochemistries were elucidated by analysis of NMR, MS data, and TDDFT CD calculations. The cytotoxic effects of 1-4 were preliminarily evaluated in HL-60 and A-549 cells. Compound 1 was active against both HL-60 and A-549 cells with IC50s 9.2 and 39.7 μM, respectively, while 2 showed weaker activity only against HL-60 cells (IC50 37.8 μM). |
| Keywords: | Sorbicillinoids Marine derived fungus Penicillium terrestre |
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