| 新型含芳氧乙酸酯基三唑酮类化合物的合成及生物活性研究 |
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| 引用本文： | 卢彦昌,刘建兵,梁华,史延年,方建新.新型含芳氧乙酸酯基三唑酮类化合物的合成及生物活性研究[J].有机化学,2006,26(11):1571-1575. |
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| 作者姓名： | 卢彦昌 刘建兵 梁华 史延年 方建新 |
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| 作者单位： | 南开大学元素有机化学国家重点实验室,元素有机化学研究所,天津,300071 |
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| 基金项目： | 国家自然科学基金(No．20172030)，教育部科学技术研究重点(No．105046)资助项目． |
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| 摘 要： | 通过芳氧乙酸与2-溴-4,4-二甲基-1-(1H-1,2,4-三唑-1-基)-3-戊酮反应, 合成了14个新型含芳氧乙酸酯基三唑酮类化合物. 所有化合物均经核磁、元素分析确证, 部分化合物进行了红外和质谱的测定. 生物活性测试表明部分化合物具有良好的生物活性.
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| 关 键 词： | 1H-1 2 4-三唑 芳氧乙酸酯 合成 生物活性 |
| 收稿时间： | 11 15 2005 12:00AM |
| 修稿时间： | 07 13 2006 12:00AM |
Synthesis and Biological Activities of 1H-1,2,4-Triazole Derivatives Containing Aryloxyacetate Unit |
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| LU,Yan-Chang,LIU,Jian-Bing,LIANG,Hua,SHI,Yan-Nian,FANG,Jian-Xin.Synthesis and Biological Activities of 1H-1,2,4-Triazole Derivatives Containing Aryloxyacetate Unit[J].Chinese Journal of Organic Chemistry,2006,26(11):1571-1575. |
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| Authors: | LU Yan-Chang LIU Jian-Bing LIANG Hua SHI Yan-Nian FANG Jian-Xin |
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| Institution: | Institute and State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071 |
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| Abstract: | Fourteen new 1H-1,2,4-triazole derivatives containing aryloxyacetate unit were synthesized by the reaction of 2-bromo-4,4-dimethyl-1-(1H-1,2,4-triazol-1-yl)pentan-3-one with substituted phenoxyacetic acid derivatives, the structures of which have been characterized by 1H NMR and elemental analysis. Bioassay showed that some of them exhibited high biological activities. |
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| Keywords: | 1H-1 2 4-triazole aryloxyacetate synthesis biological activity |
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