Angiogenin induces nitric oxide release independently from its RNase activity |
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Authors: | Trouillon Raphaël Kang Dong-Ku Chang Soo-Ik O'Hare Danny |
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Institution: | Department of Bioengineering, Imperial College London, London, UK SW7 2AZ. raphael.trouillon06@imperial.ac.uk |
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Abstract: | Nitric oxide (NO), a biological mediator involved in vascular physiology, was sensed electrochemically using a microelectrode array. Angiogenin was shown to trigger nitric oxide synthase (NOS) activity in human umbilical vein endothelial cells and embryonic stem cell derived endothelial cells independently from its RNase activity. |
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