Electrochemical sensing of trypanosome- and flavivirus-related neglected tropical diseases |
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Authors: | Dhésmon Lima Ana Carolina Mendes Hacke Benjamin Ulmer Sabine Kuss |
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Institution: | Department of Chemistry, University of Manitoba, 144 Dysart Road, R3T 2N2, Winnipeg, MB, Canada |
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Abstract: | Virus infections and parasitic diseases that are often found in tropical countries represent a large burden on societies in those regions but are unfortunately rarely studied by electrochemistry. These neglected tropical diseases (NTDs) are a concerning issue, especially in developing nations because a challenged healthcare system often negatively affects the economy. Besides the exploration of new treatment strategies, the development of early diagnostic methods is crucial to attenuate negative impacts related to NTDs. This review highlights the most recent developments of electrochemical biosensing efforts for five NTDs, Chagas disease, leishmaniasis, sleeping sickness, dengue fever and Zika virus infection, which affect a number of Latin American, African, and Asian countries. Special focus is placed on the design and fabrication of genosensors and immunosensors, designed as innovative and promising diagnostic tools with the potential of being integrated into portable systems to advance the development of point-of-care devices. |
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Keywords: | Electrochemical sensors Biosensor Clinical diagnosis Chagas disease Leishmaniasis Zika virus Dengue fever |
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