A ratiometric near-infrared naphthalimide-based fluorescent probe with high sensitivity for detecting Fe2+ in vivo |
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| Authors: | Lina Huang Yu Chen Yuqiang Zhao Yumin Wang Junwei Xiong Junfeng Zhang Xianghua Wu Ying Zhou |
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| Affiliation: | College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China; College of Chemical Science and Technology, Yunnan University, Kunming 650091, China |
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| Abstract: | Iron is one of the essential trace elements in the human body. It plays an important role in human biology and pathology. Deregulation of iron levels in cells is associated with disease development. In this work, we synthesized a novel near-infrared intramolecular charge transfer (ICT) based ratiometric fluorescent probe to detect Fe2+, by using naphthalimide and indole moieties as building blocks. Our work showed that the radiometric probe has excellent selectivity, sensitivity and rapid response. Moreover, we could successfully perform real-time monitoring of Fe2+ in HeLa cells and C. elegans. |
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| Keywords: | Fluorescent probe Ratiometric Fe2+ Naphthalimide Near-infrared |
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