A bicyclo[3.2.1]octanoid neolignan and toxicity of the ethanol extract from the fruit of <Emphasis Type="Italic">Ocotea heterochroma</Emphasis> |
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Authors: | Luis E Cuca Paula Leon Ericsson D Coy |
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Institution: | (1) Universidad Nacional de Colombia, Facultad de Ciencias, Departamento de Quimica, Laboratorio de Investigacion en Productos Naturales Vegetales, AA 14490, Cra 30 45-03, Ciudad Universitaria, Bogota D.C., Colombia |
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Abstract: | A new bicyclo3.2.1]octanoid neolignan rel-(7S,8R,1′S,2′R,3′S)-Δ8′-2′-hydroxy-5,1′,3′-trimethoxy-3,4methylenedioxy-7,3′,8,1′-neolignan (1) was isolated from ethanol extract from the fruit of Ocotea heterochroma Mez & Sodiro ex Mez as well as the known compounds β-friedelanol (2), meso-dehydroguaiaretic acid (3), and yangambin (4), whose structures were elucidated on the basis of their comprehensive spectroscopic analysis including 2D NMR data. Lethality
bioassay using brine shrimp (Artemia salina Leach) was evaluated with the ethanol extract from the Ocotea heterochroma’s fruit. The toxicity of this extract was greater than the toxicity of those fractions obtained in a first solvent partition
(benzene, ethyl acetate, and butanol subfractions) and that of a mixture of acetylated 2′-epimers from the new neolignan 1.
Published in Khimiya Prirodnykh Soedinenii, No. 2, pp. 158–160, March–April, 2009. |
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Keywords: | Ocotea heterochroma Lauraceae bicyclo[3 2 1]octanoid neolignan lethality bioassay Artemia salina |
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