The complexes of metal ions with fluoroquinolones

Fluoroquinolones are defined as an important group of synthetic antibacterial compounds, having a fluorine atom at position 6 and a piperazine ring at position 7 of quinolone-3-carboxylic acid. It was proved that the activity of quinolones was decreased in the environment of certain metal ions by the formation of sparingly soluble metal complexes. The proposed reason for such maintenance might be the chelate bonding of the quinolone to the metal. Again, it was proposed that metal ions, especially magnesium ions, were engaged in the mode of action of quinolones. In this review article, selected structures of fluoroquinolones metal complexes were performed and discussed in terms of their therapeutic application. The nuclease activity and antibacterial activity tests were presented and the effects of metal complexes were compared to free fluoroquinolones. Finally, the results were introduced. The article is published in the original.