Elemental concentration in the cortex and hippocampus of Wistar rats by X-ray total reflection fluorescence with synchrotron radiation |
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| Authors: | R. F. B. Serpa E. F. O. De Jesus M. J. Anjos R. T. Lopes M. G. T. do Carmo S. Moreira M. S. Rocha A. M. B. Martinez |
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| Affiliation: | (1) Nuclear Instrumentation Laboratory, COPPE/UFRJ, P.O. Box 68509, 21941-972, Rio de Janeiro, Brazil;(2) Nuclear Instrumentation Laboratory, COPPE/UFRJ; Physical Institute, UERJ, P.O. Box 68509, 21941-972, Rio de Janeiro, Brazil; Brazil;(3) Nuclear Instrumentation Laboratory, COPPE/UFRJ; Physical Institute, UERJ, P.O. Box 68509, 21941-972, Rio de Janeiro, Brazil; Brazil;(4) Nuclear Instrumentation Laboratory, COPPE/UFRJ, P.O. Box 68509, 21941-972, Rio de Janeiro, Brazil;(5) Nutrition Institute, UFRJ, Brazil;(6) State University of Campinas, FEC/UNICAMP, Brazil;(7) Department of Basics and Clinic Pharmacology, UFRJ, Brazil;(8) Department of Histology and Embryology, UFRJ, Brazil |
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| Abstract: | Summary The study of trace element levels is of great importance due to their relevance in agingand several neurodegenerative diseases. This work compares the elemental concentrations in different postnatal ages and between the temporal cortex, entorhinal cortex and hippocampus from Wistar rats, using X-ray total reflection fluorescence with synchrotron radiation. Ten elements were determined in brain samples: Ti, Cr, Mn, Fe, Cu, Zn, (at trace level) and P, S, Cl and K (at major levels). The elements that increased with aging in cortical areas were: S, K, Fe, Cu and Zn. Ca and Zn levels decreased with advancing age in the hippocampus. In addition to this, Ti, Mn and Fe levels were more conspicuous in the entorhinal cortex. |
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