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Steroid derivatives of purine-6(1H)-thione (1a-c) |
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| Authors: | F I Carroll Abraham Philip Anna M Ferguson Monroe F Wall |
| Abstract: | The products obtained as a result of the alkylation of purine-6(1H)-thione, and 6-alkylthiopurines with steroidal-21-(p-bromobenzenesullonates) (H) and 3-methoxy-16α-bromoestra-1,3,5 (10)-tricne-17-one (IV) is reported. The ratio of 9-alkylated to 7-alkylated purine in the alkylation of 6-methylthiopurine (VI) is presented. The use of the S-diphenylmethylprotecling group in the syntheses of sensitive 9-steroidal-9H-purine-6(1H)-thiones is discussed. |
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