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| 晚期糖基化终末产物荧光光谱测量系统的设计 | |
| 引用本文： | 许良元,朱灵,张龙,余锋,刘勇,张弓,吴路生.晚期糖基化终末产物荧光光谱测量系统的设计[J].光谱学与光谱分析,2009,29(8):2298-2301. |
| 作者姓名： | 许良元 朱灵 张龙 余锋 刘勇 张弓 吴路生 |
| 作者单位： | 1. 中国科学院安徽光学精密机械研究所,安徽,合肥,230031;安徽农业大学工学院,安徽,合肥,230036 2. 中国科学院安徽光学精密机械研究所,安徽,合肥,230031 3. 安徽省立医院,安徽,合肥,230001 4. 加拿大温泥伯大学,马尼托巴,R3T6A5 |
| 基金项目： | 中国科学院知识创新工程青年人才领域专项前沿项目 |
| 摘 要： | 提出了一种利用荧光光谱技术测量晚期糖基化终末产物的方法,阐述了该荧光光谱测量系统的测量原理,设计并搭建了该荧光光谱测量系统.利用该系统对365,370,375,380,385 nm波段进行了激发光谱扫描测试,得出375 nm为最佳激发波长;采用375 nm的单色光作为激发光源,分别对正常人和糖尿病患者的皮肤进行了荧光光谱检测,发现两者在450 nm附近的荧光存在明显的差异.实验结果证明该荧光光谱测量系统快速、无创、简单,可应用于对糖尿病、人体衰老、氧化应激等病情进行早期预测和诊断. |
| 关 键 词： | 晚期糖基化终末产物 荧光光谱 无损测量 |
| 收稿时间： | 2008/7/16 |
Design of Advanced Glycation Endproducts Fluorescence Spectrum Detecting System |
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| XU Liang-yuan,ZHU Ling,ZHANG Long,YU Feng,LIU Yong,ZHANG Gong,WU Lu-sheng.Design of Advanced Glycation Endproducts Fluorescence Spectrum Detecting System[J].Spectroscopy and Spectral Analysis,2009,29(8):2298-2301. | |
| Authors: | XU Liang-yuan ZHU Ling ZHANG Long YU Feng LIU Yong ZHANG Gong WU Lu-sheng |
| Institution: | XU Liang-yuan1,2,ZHU Ling1,ZHANG Long1,YU Feng3,LIU Yong1,ZHANG Gong4,WU Lu-sheng11. Anhui Institute of Optics , Fine Mechanics,Chinese Academy of Sciences,Hefei 230031,China2. Engineering College,Anhui Agricultural University,Hefei 230036,China3. The Affiliated Provincial Hosptial of Anhui Medical University,Hefei 230001,China4. University of Winnipeg,Manitoba,R3T6A5,Canada |
| Abstract: | The method of making use of the technique of fluorescence spectrum to detect advanced glycation endproducts is discussed in the present pape. The emphasis is on the principle and structure of the fluorescence spectrum detecting system.In the end,the authors made use of the system to detect the excitation spectrum at the wavelengths of 365nm,370nm,375nm,380nm and 385nm,respectively,and the authors found that 375nm is the best excitation wavelength. At the same time,the emission spectrum was also detected on ... |
| Keywords: | Advanced glycation endproducts Fluorescence spectrum Noninvasive detection |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |