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Separation of binaphthyl enantiomers by capillary zone electrophoresis and electrokinetic chromatography
Authors:Hiroyuki Nishi
Abstract:The capillary electrophoretic (CE) separation of the enantiomers of three binaphthyl compounds is investigated. Several CE modes such as cyclodextrin (CD) modified capillary zone electrophoresis (CZE) (CD-CZE), micellar electrokinetic chromatography (MEKC), cyclodextrin electrokinetic chromatography (CD-EKC), etc. are employed for the simultaneous enantiomer separation of the three solutes. The successful separation was achieved by combining two modes, in other words by using more than two chiral selectors. A development of the CE enantiomer separation is demonstrated for the binaphthyl compounds. The enantioselectivity of binaphthyl compounds is alo briefly discussed.
Keywords:Capillary zone electrophoresis  Electrokinetic chromatography  Enantiomer separation  Binaphthyl compounds  Cyclodextrin  Bile salt
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