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Synthetic Antitumor Vaccines Containing MUC1 Glycopeptides with Two Immunodominant Domains-Induction of a Strong Immune Response against Breast Tumor Tissues |
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| Authors: | Gaidzik Nikola Kaiser Anton Kowalczyk Danuta Westerlind Ulrika Gerlitzki Bastian Sinn Hans Peter Schmitt Edgar Kunz Horst |
| Institution: | 1. Johannes Gutenberg‐Universit?t Mainz, Duesbergweg 10–14, 55128 Mainz (Germany);2. Gesellschaft zur F?rderung der analytischen Wissenschaften e.V. ISAS‐Institute for Analytical Sciences, Otto‐Hahn‐Strasse 6b, 44227 Dortmund (Germany);3. Johannes Gutenberg‐Universit?t Mainz, Universit?tsmedizin, Institut für Immunologie, Langenbeckstrasse 1, Geb. 708, 55101 Mainz (Germany);4. Universit?t Heidelberg, Pathologisches Institut, Sektion Gyn?kopathologie, Im Neuenheimer Feld 220, 69120 Heidelberg (Germany) |
| Abstract: | A shot in the arm for cancer treatment: Two MUC1 tetanus toxoid vaccines were synthesized and induced a strong immune response in mice. The antibodies elicited by the vaccines show a high selectivity for the tumor cells in mammary carcinoma tissues and also distinguish between tumor tissues at different stages. |
| Keywords: | antitumor vaccines glycopeptide antigens sialyl‐TN antigens tetanus toxoid tissue section labeling |
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