Conformation of poly(L-glutamic acid) in aqueous solutions of linear amphiphiles with a cationic group at both ends |
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| Authors: | K. KAMIO M. SAKAI A. KAMINAGA I. SATAKE K. HAYAKAWA |
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| Affiliation: | (1) Department of Chemistry and BioScience Faculty of Science, Kagoshima University 1-21-35 Korimoto, Kagoshima 890-0065 Japan e-mail: hayak@sci.kagoshima-u.ac.jp Tel.: +81-99-2858101 Fax: +81-99-2858117, JP;(2) Department of Industrial Chemistry Kyushu Sangyo University, Matsukadai Higashi-ku, Fukuoka 813-8503, Japan, JP |
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| Abstract: | The conformations of poly(l-glutamic acid) [P(Glu)] in solutions of the bipolar amphiphile 1,20-icosanediylbis(alkylammonium chloride) [C20(RA)2], where RA includes trimethylammonium (TMA), dimethylammonium (DMA), or methylammonium (MA), were investigated with measurements of the circular dichroism spectra at 10–35 °C. All C20(RA)2 induced an α-helix of P(Glu) in the aqueous solutions. The residue molar ellipticity at 222 nm showed a similar dependence on the amphiphile concentration (C s) below 0.5 of the ratio of 2C s to the residue concentration (C p) of P(Glu), but it separated into three directions at 2C s/C p>0.5. C20(MA)2 induced an α-helix of P(Glu) at 2C s/C p<0.5 followed by a helix aggregate at 2C s/C p>0.5. C20(DMA)2 and C20(TMA)2 also induced an α-helix, but a helix aggregate. C20(TMA)2 indicated a strong temperature dependence and did not induce a complete α-helix at 35 °C. Received: 20 June 2001 Accepted: 6 September 2001 |
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| Keywords: | Polypeptide conformation Poly(l-glutamic acid) Bolaform surfactant Circular dichroism spectra |
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