Model studies for the synthesis of galbonolide B |
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| Authors: | Eshelby James Goessman Matthias Parsons Philip J Pennicott Lewis Highton Adrian |
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| Institution: | Pfizer Pharmaceuticals Limited, Sandwich, Kent, CT13 9NJ, UK. |
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| Abstract: | The construction of the fourteen membered ring present in galbonolide B 1 is reported. The 10,11-diene system present in the southern portion of has been constructed using an ester enolate rearrangement/silicon mediated fragmentation cascade, whilst the macrocycle has been synthesised following a Johnson rearrangement/mercury assisted ring closure protocol. |
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