Synthesis of N-benzyloxycarbonyl-N-methylaminoacids from oxazolidine-5-one derivatives |
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| Authors: | G. I. Chipens V. A. Slavinskaya D. É. Sile É. Kh. Korchagova M. Yu. Katkevich V. D. Grigor'eva |
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| Affiliation: | (1) Institute of Organic Synthesis, Latvian Academy of Sciences, Riga |
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| Abstract: | Hydrogenolysis of 3-benzyloxycarbonyloxazolidine-5-one and 3-benzyloxycarbonyl-4-benzyloxazolidine-5-one by Et3SiH in the presence of F3.CCO2H is demonstrated to be a convenient method for preparing substituted N-methylaminoacids. In contrast with catalytic hydrogenation on Pd/C catalyst, the benzyloxycarbonyl is not removed and the methyl is not lost using this method.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 681–683, May, 1992. |
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