| KMnO4-甲醛化学发光体系测定对乙酰氨基酚 |
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| 引用本文： | 王书民,樊雪梅,杨喆,陈凤英,郑行望.KMnO4-甲醛化学发光体系测定对乙酰氨基酚[J].分析试验室,2012(6):20-23. |
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| 作者姓名： | 王书民 樊雪梅 杨喆 陈凤英 郑行望 |
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| 作者单位： | 商洛学院化学与化学工程系;陕西师范大学化学与材料科学学院 |
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| 基金项目： | 国家自然科学基金资助项目(20575040);陕西省教育厅自然科学专项基金资助项目(08JK278);商洛学院服务地方经济社会发展专项资助项目(11SKY-FWDF004)资助 |
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| 摘 要： | 基于对乙酰氨基酚在酸性介质下对KMnO4-甲醛化学发光体系强烈的增敏作用,建立了对乙酰氨基酚的流动注射化学发光测定方法。在最佳测试条件下,方法对对乙酰氨基酚的检出限(S/N=3)为1.0×10-10mol/L,线性范围为1.0×10-9～1.0×10-5mol/L对乙酰氨基酚,相关系数R为0.9993;对1.0×10-6mol/L的对乙酰氨基酚溶液平行测定11次,其RSD为1.1%。该方法可应用于药物中对乙酰氨基酚含量的测定。
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| 关 键 词： | 化学发光 流动注射 KMnO4 甲醛 对乙酰氨基酚 |
Potassium permanganate-formaldehyde chemiluminescence system for determination of acetaminophen |
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| WANG Shu-min,FAN Xue-mei,YANG Zhe,CHEN Feng-ying,and ZHENG Xing-wang.Potassium permanganate-formaldehyde chemiluminescence system for determination of acetaminophen[J].Chinese Journal of Analysis Laboratory,2012(6):20-23. |
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| Authors: | WANG Shu-min FAN Xue-mei YANG Zhe CHEN Feng-ying and ZHENG Xing-wang |
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| Institution: | 1.Department of Chemistry and Chemical Engineering,Shangluo University,Shangluo 726000;2.School of Chemistry and Materials Science,Shaanxi Normal University,Xi’an 710062) |
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| Abstract: | A sensitive flow injection chemiluminescence(FL-CL) method for the determination of acetaminophen was developed.The method was based on that acetaminophen could inhibit the CL reaction of formaldehyde and potassium permanganate in hydrochloric acid.Under the optimized conditions,acetaminophen was determined.The detection limit of the method is 1.0×10-10mol/L acetaminophen,the linear range for acetaminophen is 1.0×10-9~1.0×10-5mol/L.The relative standard deviation is 1.1% for 1.0×10-6mol/L acetaminophen in 11 replicate measurements.The method was successfully applied to the determination of acetaminophen in medicament samples. |
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| Keywords: | Chemiluminescence Flow Injection Potassium Permanganate Formaldehyde Acetaminophen |
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