Polyhydroxylated steroids from the octocoral Isis hippuris |
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Authors: | Wei-Hua ChenShang-Kwei Wang Chang-Yih Duh |
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Institution: | a Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan b Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan c Centers for Asia-Pacific Ocean Research and Translational Biopharmaceuticals, National Sun Yat-sen University, Kaohsiung 804, Taiwan |
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Abstract: | The specimens for previous studies on the secondary metabolites of the Formosan octocoral Isis hippuris were all collected at Green Island. In the course of our studies on bioactive compounds from marine organisms, the acetone-solubles of the Formosan octocoral I. hippuris collected at Orchid Island has led to the isolation of six new polyoxygenated steroids (1-6), along with a known compound 7. Compound 6 possesses a new type of steroid side chain moiety. The structures of these compounds were determined on the basis of their spectroscopic and physical data. The anti-HCMV (human cytomegalovirus) activity and cytotoxicity against selected cell lines of 1-7 were evaluated. Compound 3 exhibited inhibitory activity against HCMV, with an EC50 values of 2.0 μg/mL, respectively. Compound 7 displayed cytotoxicity against P-388 and A-549 cell lines with ED50 values of 3.2 and 3.86 μg/mL, respectively. |
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Keywords: | Isis hippuris Polyhydroxylated steroids Cytotoxicity Anti-HCMV |
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