| 2-羰基-3-苯基丙酸芳甲酰腙二(2,4-二氯苄基)锡配合物的合成、晶体结构及生物活性 |
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| 引用本文： | 蒋伍玖,谭宇星,庾江喜,朱小明,张复兴,邝代治.2-羰基-3-苯基丙酸芳甲酰腙二(2,4-二氯苄基)锡配合物的合成、晶体结构及生物活性[J].无机化学学报,2016,32(8):1383-1390. |
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| 作者姓名： | 蒋伍玖 谭宇星 庾江喜 朱小明 张复兴 邝代治 |
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| 作者单位： | 衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008 |
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| 基金项目： | 国家自然科学基金（No.21273043）和上海市科委资助项目（No.13DZ2275200）资助。 |
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| 摘 要： | 二(2,4-二氯苄基)二氯化锡分别与2-羰基-3-苯基丙酸苯甲酰腙及2-羰基-3-苯基丙酸水杨酰腙反应,合成了2个取代苄基锡配合物(C1、C2),通过元素分析、IR、1H NMR、13C NMR、119Sn NMR、X射线单晶衍射以及热重分析等表征了配合物结构。测试了配合物对癌细胞Hela、MCF7、Hep G2、Colo205、NCI-H460以及正常人体胚肾细胞HEK293、正常人体肝细胞HL7702的体外抑制活性;在Tris-HCl缓冲溶液中,以EB做为荧光探针,用荧光光谱法初步研究了配合物与小牛胸腺DNA的相互作用。结果表明:配合物C1、C2对5种癌细胞都有明显的抑制作用,配合物C2对HEK293、HL7702的细胞毒性远小于C1;配合物C1与小牛胸腺DNA作用是插入结合与静电结合共同作用所致,配合物C2与小牛胸腺DNA作用是插入结合作用所致。
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| 关 键 词： | 有机锡配合物 酰腙 合成 晶体结构 生物活性 |
| 收稿时间： | 2016/3/31 0:00:00 |
| 修稿时间： | 2016/6/12 0:00:00 |
Syntheses, Crystal Structures and Biological Activity of 2-Oxo-3-phenylpropionic Acid Aroyl Hydrazone Di-2,4-dichlorobenzyltin Complexes |
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| JIANG Wu-Jiu,TAN Yu-Xing,YU Jiang-Xi,ZHU Xiao-Ming,ZHANG Fu-Xing and KUANG Dai-Zhi.Syntheses, Crystal Structures and Biological Activity of 2-Oxo-3-phenylpropionic Acid Aroyl Hydrazone Di-2,4-dichlorobenzyltin Complexes[J].Chinese Journal of Inorganic Chemistry,2016,32(8):1383-1390. |
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| Authors: | JIANG Wu-Jiu TAN Yu-Xing YU Jiang-Xi ZHU Xiao-Ming ZHANG Fu-Xing and KUANG Dai-Zhi |
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| Institution: | Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China,Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China,Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China,Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China,Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China and Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China |
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| Abstract: | Two substituted benzyltin complexes has been synthesized via the reaction of 2-oxo-3-phenylpropionic acid aroyl hydrazone with di-2,4-dichlorobenzyltin dichloride. The complexes C1 and C2 have been characterized by IR, UV-Vis, 1H NMR, 13C NMR 119Sn NMR spectra, elemental analysis and the crystal structures have been determined by X-ray diffraction. In vitro antitumor activities of both complexes were evaluated by 3-(4,5-dimethylthiazoly-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against five human cancer cell lines(Hela, MCF7, HepG2, Colo205, NCI-H460) and two human cell lines(HEK293, HL7702). Two Complexes exhibited strong antitumor activity. Moreover, C2 less toxic than C1. The interaction between complexes and calf thymus DNA were studied by EB fluorescent probe. The results show that the interaction of C1 with calf thymus DNA were intercalation and electrostatic attraction. However, the C2 were intercalation. |
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| Keywords: | organotin complex hydrazone synthesis crystal structure biological activity |
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