Synthesis of enantiomeric 9-(2′,3′,4′-trihydroxybutyl)adenine derivatives from l-ascorbic and d-isoascorbic acids |
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| Authors: | Andrzej E Wróblewski Wies?awa Karolczak |
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| Institution: | Bioorganic Chemistry Laboratory, Faculty of Pharmacy, Institute of Chemistry, Medical University of ?ód?, 90-151 ?ód?, Muszyñskiego 1, Poland |
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| Abstract: | l-Ascorbic and d-isoascorbic acids were employed in syntheses of 9-(2′,3′,4′-trihydroxybutyl)adenines protected at 3′ and 4′ oxygens (all four enantiomers) and at 2′ oxygen (2′S,3′R and 2′S,3′S enantiomers). |
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| Keywords: | purine acyclonucleosides alkylation of adenine stereoisomers |
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