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Synthesis of chiral 2′,3′-pyranone(pyrrolidinone)-fused tryptamines |
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| Authors: | Emmanuel DardennesÁrpád Kovács-Kulyassa Andrea RenzettiJanos Sapi Jean-Yves Laronze |
| Institution: | UMR CNRS 6013 ‘Isolement, Structure, Transformations et Synthèse de Produits Naturels’, IFR 53 ‘Biomolécules’ Faculté de Pharmacie, Université de Reims-Champagne-Ardenne, 51 rue Cognacq-Jay, F-51096 Reims Cedex, France |
| Abstract: | Chiral pyrano- and pyrrolidino-fused tryptamines were prepared by a diasteroselective trimolecular condensation between indole, Garner's aldehyde and Meldrum's acid, followed by selective functional group transformations. |
| Keywords: | multicomponent reaction trimolecular condensation Garner's aldehyde diastereoselective synthesis chiral tryptamine derivatives |
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